S.No. Chemical Name of the Intermediate CAS No. Related to API Therapeutic category
1 5-bromo-2-chloro-4'-ethoxydiphenylmethane 461432-23-5 Dapagliflozin Anti Diabetic
2 5-bromo-2-chlorophenyl)(4-ethoxyphenyl) methanone 461432-22-4
3 2,3,4,6-Tetrakis-O-trimethylsilyl-Dgluconolactone 32384-65-9
4 Methyl 1-C- [4-chloro-3- [(4-ethoxyphenyl) methyl] phenyl]-alpha-D-gluco pyranoside 714269-57-5
5 (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4ethoxyphenyl)methyl]phenyl]-D-glucitol tetra acetate 461432-25-7
6 3-(3-Chloropropyl)-1,3-dihydro-7, 8-dimethoxy- 2H-3-benzazepin-2-one 85175-59-3 Ivabradine HCl Cardio vascular
7 1,3-Dihydro-3- (3-iodopropyl)-7,8-dimethoxy- 2H-3-benzazepin-2-one 148870-57-9
8 [(S)-3-(3-(((3,4-dimethoxy bicyclo [4.2.0] octa-1 (6), 2,4-trien-7-yl) methyl) (methyl) amino) propyl)-7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] `azepin-2-one] 1086026-31-4
9 4-(4-chlorophenyl)-1H-benzo[d][1,2] oxazin-1one 2224-83-1 Chlorthalidone Cardio vascular
10 3-(4-chlorophenyl) isoindolin-1-one 2224-77-3
11 2-Chloro-5- (2,3-dihydro-3-oxo-1H-isoindol-1yl)-benzene sulfonamide 82875-49-8
12 2-Chloro-3, 4-dihydroxyacetophenone 99-40-1 Isoproterenol HCl Cardio vascular
13 1-(3,4-dihydroxyphenyl)-2-(isopropyl amino) ethan-1-one Hydrochloride 16899-81-3
14 (3R, 4S, 5R)-2-(6-amino-2-chloro-9H-purin-9yl)-5-(hydroxymethyl) tetrahydrofuran-3, 4-diol 146-77-0 Regadenoson Contrast Agent
15 (3R, 4S, 5R)-2-(6-amino-2-hydrazinyl-9H-purin-9-yl)-5-(hydroxymethyl) tetrahydrofuran-3,4-diol 15763-11-8
16 Ethyl1- (6-amino-9- ((3R, 4S, 5R)-3,4dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate 313348-29-7
17 1-(6-amino-9- ((3R, 4S, 5R)-3,4-dihydroxy-5 (hydroxymethyl) tetrahydrofuran-2-yl)-9H-purin2-yl)-1H-pyrazole-4-carboxylic acid 313348-16-2
18 Phenyl Hydrazine Hydrochloride 59-88-1 Edaravone To treat Amyotrophic Lateral Sclerosis
19 1-(7,8-diamino-1, 2,4,5-tetrahydro-3H-1, 5methanobenzo [d] azepin-3-yl)-2,2,2trifluoroethan-1-one 230615-69-7 Varenicline Tartrate Smoking cessation
20 2,2,2-trifluoro-1- (6,7,9,10-tetrahydro-8H-6, 10methanoazepino [4,5-g] quinoxalin-8-yl) ethan-1-one 230615-70-0
21 Varenicline Free Base 249296-44-4
22 N,N-dimethyl-4-nitrosoaniline Hydrochloride 42344-05-8 Methylene Blue To treat methemoglobinemia
23 N1,N1-dimethylbenzene-1,4-diamine (DMPPDA) 99-98-9
24 2-Amino-5-dimethylaminophenyl Thiosulphonic acid 43035-11-6
25 2-(3,4-dimethylphenyl)-5-methyl-1, 2-dihydro-3H-pyrazol-3-one 277299-70-4 Eltrombopag Medication for conditions that lead to thrombocytopenia
26 Eltrombopag Free Acid 496775-61-2
27 (2R, 3R)-3-(2,3-dihydrobenzo [b][1,4] dioxin-6yl)-3-hydroxy-2-(((S)-2-hydroxy-1-phenylethyl) amino)-1-(pyrrolidin-1-yl)propan-1-one 491833-26-2 Eliglustat Tartrate Gaucher Disease type-1
28 (1R, 2S)-1-(2,3-dihydrobenzo [b][1,4] dioxin-6yl)-2-(((S)-2-hydroxy-1-phenylethyl) amino)-3(pyrrolidin-1-yl) propan-1-ol 491833-27-3
29 (1R, 2S)-2-amino-1- (2, 3-dihydrobenzo [b][1,4] dioxin-6-yl)-3-(pyrrolidin-1-yl) propan-1-ol 491833-28-4
30 Eliglustat Free Base 491833-29-5
31 (2S)-1-[[(2-Amino-1,1-dimethylethyl)amino]acetyl]-2-pyrrolidinecarbonitrile 794460-89-2 Anagliptin Antidiabetic
32 2-Methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 739364-95-5
33 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 6642-31-5 Theophylline COPD & Asthma
34 6-amino-1,3-dimethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione 6632-68-4
35 5,6-diamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 5440-00-6
36 N-(5-amino-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)formamide 7597-60-6
37 3-(4-chlorophenyl) propanoic acid 2019-34-3 Pitolisant HCl Narcolepsy with or without cataplexy
38 3-(4-chlorophenyl) propan-1-ol 6282-88-8
39 3-(4-chlorophenyl) propyl methane sulfonate 61440-60-6
40 3-(piperidin-1-yl) propan-1-ol 104-58-5
41 Sodium 3-(piperidin-1-yl) propan-1-olate 462115-38-4
42 6-amino-1, 3-diethylpyrimidine-2, 4(1H, 3H)dione 41740-15-2 Istradefylline Parkinson's disease
43 6-amino-1, 3-diethyl-5-nitrosopyrimidine-2,4(1H, 3H)-dione 89073-60-9
44 5,6-diamino-1, 3-diethylpyrimidine-2, 4(1H,3H)-dione 1785764-26-2
45 (E)-3-(3,4-dimethoxyphenyl) acrylic acid 14737-89-4
46 (E)-N- (6-amino-1, 3-diethyl-2, 4-dioxo-1, 2,3,4tetrahydropyrimidin-5-yl)-3-(3,4dimethoxyphenyl) acrylamide 187393-68-6
47 (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-3, 7dihydro-1H-purine-2, 6-dione 155270-98-7
48 ethyl 7-bromo-2,2-dimethylheptanoate 123469-92-1 Bempedoic acid Hypercholesterolemia
49 diethyl 8-cyano-2,2,14,14-tetramethyl-8-tosylpentadecanedioate 738606-44-5
50 diethyl 2,2,14,14-tetramethyl-8-oxopentadecanedioate 738606-43-4
51 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid 413624-71-2
52 2-(benzyl(methyl)amino)acetaldehyde 166947-11-1 Revefenacin Chronic obstructive pulmonary disease (COPD)
53 1-(2-(methylamino)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate 743460-48-2
54 piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate 171722-92-2